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[64] reported that, in mouse C2C12 myoblasts under basal conditions, low curcumin concentrations (15 M) did not alter cell morphology or viability but did elicit a mild increase in ROS levels associated with elevated mitochondrial mass and membrane potential

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Of note, none of the 5 previously identified targets of glutathionylation (peroxiredoxin 1, peroxiredoxin 2, thioredoxin, profilin and vimentin) were present on the antibody array used here

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glutathione's antioxidant activity may dampen this response Mechanism 4: Thyroid Hormone Metabolism Support Thyroid hormone conversion - the transformation of inactive T4 (thyroxine) to active T3 (triiodothyronine) - is performed by iodothyronine deiodinase enzymes (DIO1, DIO2, DIO3), which are selenoproteins that depend on the glutathione/thioredoxin antioxidant system for their activity and regeneration