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doi: 10.1016/j.cmet.2017.08.022 67 KyriachenkoY.FalalyeyevaT.KorotkyiO.MolochekN.KobyliakN

Patients with AITD show thyroid lymphocyte infiltration and an increase in the titer of thyroid autoimmune antibodies, thereby altering the integrity of thyroid follicle epithelial cells and dysregulating their metabolism and immune function, leading to a decrease in multi-tissue metabolic activity

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To prevent IMR-5/75 from detaching, the plates were treated beforehand with 100 g/mL Poly-D-Lysine (Sigma-Aldrich)

The effect of INSL-5 on glucose homeostasis is less clear

How Therapeutic Peptides Work Therapeutic peptides exert their effects through several mechanisms: Receptor binding and signal transduction: Many peptides bind to specific cellsurface or intracellular receptors, triggering cascade reactions that produce targeted physiological responses