Forward-Looking Statements and Article Accuracy : This article reflects information available as of June 2026 and was prepared using reasonable care to be accurate and useful at the time of publication

Key Points Activation of the androgen receptor (AR) is crucial for tumor cell progression and survival of prostate cancer, and androgen deprivation therapy remains the main clinical approach in men with locally advanced tumors Current therapies incompletely suppress the androgenAR axis, but a multiple therapeutic approach, targeting androgens and their receptor, has potential to improve clinical outcomes Treatment of prostate cancer cells with 5-reductase inhibitors (5ARIs) inhibits cellular pathways regulating metabolism, cell growth and proliferation, triggering apoptosis and decreasing prostate size Although 5ARI treatment reduces the risk of developing prostate cancer, patients treated with these drugs have tumors with higher Gleason scores than those who receive placebo Use of 5ARIs to prevent and treat prostate cancer remains controversial, and further investigation is necessary to understand the presence of more-aggressive tumors in patients receiving these drugs This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

GSH and GSSG metabolomics correlations for GSH metabolic process classification, MitoCarta scores for mitochondrial localization classification, and TrSSP scores for transmembrane transporter activity classification (Fig
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Omega-3 fatty acids in avocados help maintain brain cell structure and promote healthy brain aging
If you fall into one or more of these categories, your healthcare provider might recommend more frequent B12 monitoring and supplementation