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GPER may increase the expression of OPG while suppressing the expression of RANKL, thereby reducing bone resorption

This idea is supported by ciliary elongation in cultured cells knocked down for Dync2li1 in our study, and the absence of cilia or ciliary shortening in the ventral node of mouse embryos lacking Dync2li1 in a previous study (81)

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This process is intimately connected to longevity

On top of that, selenium connects with thyroid and testosterone to influence hormone production