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Targeting early degenerative changes, such as synaptic loss, axonal transport disruption, mitochondrial compromise, and glial dysfunction, may prove more effective than attempting to reverse advanced neuronal death [27, 28]

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The pEGCG can lower lactate dehydrogenase release and decrease caspase-3 activity but not decrease caspase-3 activity caused by 6-OHDA

Glutathione enzyme activity is improved, and sufficient glutathione levels are restored by curcumin, the active ingredient in turmeric

Corkum, Emma Co Biological Psychiatry.2026;[Epub] CrossRef Hypothalamus Amyloid Levels Are Associated with Early Sex-Dependent Alterations in Peripheral Energy Homeostasis in TgF344-AD Rats Caleb M

Gut Microbes 17 , 2464221 (2025)