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(2018) found that sertraline causes impaired the steroidogenesis of sex hormones in male rats through the direct inhibition of steroid synthesis and its indirect effects on gene expression, and plasma LH levels and LH/testosterone ratios were significantly increased, potentially triggering compensatory hypogonadism

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Lifestyle changes, such as being more sedentary, lack of sleep, or increased stress, can also set the stage for weight gain

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doi: 10.1158/1055-9965.Epi-05-0950 109 PearceENAnderssonMZimmermannMB