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As the disease advances, ferroptosis-induced release of damage-associated molecular patterns (DAMPs), exosomal transmission, and immune evasion mechanisms further amplify neuroinflammation and cell damage, establishing a cascade of intercellular pathological propagation that accelerates neurodegeneration

Furthermore, we explored the therapeutic efficacy in clonogenic assays using a linear quadratic model to monitor the surviving fraction, plotted in a logarithmic scale