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622 Secretion of GABA from astrocytes, likely mediated by Best1 anion channels, 623 may increase tonic inhibition thus counteracting neuronal hyperexcitability characteristic for AD

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Treatments that could address redox metabolism abnormalities include methylcobalamin with and without folinic acid in open-label studies and vitamin C and N -acetyl-l-cysteine in DBPC studies

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