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That cartridge contained two adsorbent materials: white spherical particles of macroporous, insoluble resin (20 ml) and uncoated activated carbon (240 ml).36 Due to the ultrafiltered nature of the regenerated fluid, HFR originally allowed the use of carbon adsorbents in an "uncoated form", of higher adsorptive capacity, overcoming the bioincompatibility and blood coagulation problems initially observed with HP, which necessitated the use of carbons in "coated" form, more biocompatible, but with a lower adsorption capacity.25 The resin, of a nonionic and hydrophobic nature, allowed the adsorption of medium and high molecular weight solutes, including 2-m, proinflammatory cytokines, and advanced glycation end-products (AGEs)

It neutralizes free radicalsunstable molecules that damage cells and accelerate the visible signs of ageing

D., Fang, Y., & Yang, S

The study protocol was approved by institutional animal ethics committee of our university (KMC/MNG/IAEC/032020)

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