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Structurally, it contains an extracellular N-terminal domain (NTD) and a transmembrane domain (TMD) with -helix bundles (Lei et al., 2018

Both hypertension and diabetes lead to endothelial dysfunction characterized by increased oxidative stress and activation of receptors for advanced glycation end products ([AGEs] RAGE)

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Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling