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It works by increasing the levels of insulin-like growth factor in the body, which helps to promote cell growth and division

In fact, blockade of systemic IGF-I action at the choroid plexus was sufficient to induce brain amyloidosis[326]

With respect to definition of controls, most studies recruited healthy children with no information about family history of autism spectrum disorders, although, four studies did ensure that controls did not have either a family history or sibling with autism [70, 75, 77, 87] and one screened for autism traits [59]