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doi: 10.3389/fnut.2025.1701661 Received 08 September 2025 Revised 10 November 2025 Accepted 04 December 2025 Published 05 January 2026 Volume 12 - 2025 Edited by Emanuele Micaglio, IRCCS San Donato Polyclinic, Italy Reviewed by Runzhe Xu, University of Texas Southwestern Medical Center, United States Husain Alkhaldy, King Khalid University, Saudi Arabia Updates Copyright 2026 de Carvalho, Akamine, Di Pietro, Frana, Oliveira and Lopes

1 Meticobal tablet contains the same amount of active ingredient as 1 ampoule for intravenous or intramuscular administration

For topical applications, mild irritation, redness, or itching at the application site are the most commonly reported observations

Still, it suggested the mechanism was working in humans, not just mice

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Talk to your doctor before you try any supplements to make sure they won't interact with your other medications