doi: 10.3390/pharmaceutics13010038 135 van RumundA.PavelkaL.EsselinkR
128,129 Conversely, USP4, USP10, and USP18 mitigate metabolic dysfunction by reducing hepatic steatosis, hyperglycemia, and inflammation, suggesting therapeutic potential against MASLD and T2DM
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Furthermore, the excessive adrenaline directly inhibits insulin action, worsening the underlying insulin resistance and locking the patient into a vicious, self-perpetuating cycle of metabolic and autonomic dysfunction
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