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Common reasons for treatment interruptions include: Medication supply shortages or availability issues Intolerable gastrointestinal side effects requiring a break Acute illness or surgical procedures Pregnancy or planning pregnancy (note: Wegovy must be discontinued at least 2 months before planned conception) Funding or prescription access changes Travel or lifestyle disruptions Recognising why the interruption occurred helps inform the restart strategy and prevents future discontinuations

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The SELECT cardiovascular outcomes trial actually demonstrated cardiovascular benefit rather than harm, which was reassuring

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doi: 10.1016/j.jhep.2016.06.005 65 BirisAIBirisCConstantinDBacalbasaNDimaS

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