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In addition, although changes in oxidative stress markers have been reported, direct evidence linking GLP-1RA therapy to constrained redox buffering capacity remains limited

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For instance, IGF-1R integrin complexes are reported at sites of focal adhesion [9] and IGF-1R E-cadherin complexes play a role in cell-cell adhesion [10]

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A series of secondary injury cascades, such as the release of blood metabolites, microglial activation, thrombin activity, the release of excitatory amino acids, and proinflammatory factors, are initiated (Figure 1)

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