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Conversely, inhibiting TLR4 can suppress microglial activation, alleviate neuroinflammation, improve cognitive function, and mitigate synaptic plasticity impairments and depression-like symptoms via this pathway (159, 160)

Rogovski P, Cadamuro RD, da Silva R, de Souza EB, Bonatto C, Viancelli A, et al

Int J Biochem Cell Biol (2008) 40(6-7):123845