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During Listeria monocytogenes infection, LLO promotes mitochondrial membrane permeabilization, facilitating mtDNA release and subsequent activation of the cGAS-STING pathway ( Similarly, Salmonella enterica serovar Typhimurium infection induces mitochondrial stress and mtDNA release in murine macrophages, thereby activating the cGAS-STING-dependent type I IFN response (Xu et al., 2022)

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In fact, we observed an increase of metabolic flux by using D-glucose- 13 C 6 , which produced pyruvate containing three heavy-labeled carbons (M + 3-labeled pyruvate) and decreased of extracellular glucose level in the conditionate medium

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