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and broad transcriptional effects, with gene-expression analyses identifying modulation of expression patterns associated with antioxidant defense, DNA repair, and tissue remodeling

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: Effects of weight loss

Further supporting a cardiometabolic role of GLP-1 (9-36amide), both GLP-1 (7-36amide) and GLP-1 (9-36amide), but not exendin-4, promote vasodilation in isolated and ex vivo cultured mesenteric blood vessels [201], i.e., the vasodilatory effect of GLP-1 (7-36amide) was not different relative to that of GLP-1 (9-36amide) and was likewise preserved in GLP-1R KO mice [201]

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The rationale is closer to this: if repair is only one part of the model and inflammatory tone is another, KPV gives the stack a reason to exist as a stack rather than a simple peptide pairing