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High-dose riboflavin has shown efficacy in stabilizing mutant AIFM1 and improving clinical features in some patients, marking it as a prototypical FAD-sensitive genotype

This phase 3 multicenter study, which is coordinated by Cleveland Clinics C5Research academic research organization, is enrolling 15,000 adults with overweight or obesity (BMI 27) who do not have diabetes but do have either established CVD or multiple CVD risk factors

There is no clinical study showing that two weeks, four weeks, or any other break is the correct KLOW off period

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