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Researchers should not confuse the LR3 analog evidence base with the substantially larger clinical literature on unmodified recombinant IGF-1 (mecasermin), which is a separate compound with a distinct regulatory and clinical history

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Table 2 Summarizes representative clinical studies evaluating rational combination therapies designed to suppress heterogeneity-driven resistance mechanisms across solid tumors

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10.1248/cpb.c24-00117 21 Dietrich-ZagonelF.HammermanM.BernhardssonM.EliassonP