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Most of these side effects do not require medical attention and resolve gradually over time

[DOI] [PubMed] [Google Scholar] 85.Wershil B.K., Turck C.W., Sreedharan S.P., Yang J., An S., Galli S.J., Goetzl E.J

Intranasal delivery is under study for other peptides for CNS effects and may offer noninvasive systemic access

96 participants were randomly assigned to groups of 6 multiple-ascending doses of once-weekly subcutaneous cagrilintide (final doses of 0.16, 0.30, 0.60, 1.2, 2.4, and 4.5 mg) in combination with once-weekly subcutaneous semaglutide 2.4 mg or semaglutide 2.4 mg with placebo for 20 weeks

DSIP is a naturally occurring nonapeptide, and its demonstrated properties in controlled preclinical and small human studies suggest a low risk of toxicity

10.12688/f1000research.20942.1 F1000Res