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[DOI] [PubMed] [Google Scholar] Theodorakis MJ, Carlson O, Muller DC, Egan JM

For example, if you burn 600 calories through a hard cardio workout, energy compensation may subtly influence you to burn fewer calories the rest of the day, in general, around-the-house activity

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This depletion creates a problematic cycle where reduced antioxidant protection leads to increased oxidative damage, which then promotes further fat accumulation and inflammation in the liver

Mechanically, SIRT2 interacts with forkhead box protein O1 (FoxO1)