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Many of these genes are also implicated in substance use disorders and BED, particularly those regulating serotonin (5-HT) and dopamine (DA) in the central nervous system [40, 41]

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Since ML171 is structurally related to some commonly used phenothiazine-derived anti-psychotic drugs (e.g., chlorpromazine), it may interfere with receptors for serotonin and adrenaline ( VAS2870 and VAS3947 (named VAS after the Vasopharm GmbH that developed them) are NOX-2 selective inhibitors