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A protein rhythm does not mean counting every bite or building perfect meals

Recent research indicates that GLP-1 RAs reduce hypertension development in animal models like Dahl salt-sensitive (DSS) rats [73], spontaneously hypertensive rats (SHRs) [74], and angiotensin II-infused C57BL/6 J mice [75]

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For ischemic stroke and retinal damage, two major complications of diabetes mellitus, it was shown that DPP-4 inhibition prevented inflammation and mediated neuroprotective effects (89)

As COL IV genes are expressed by the animals body wall muscles in addition to their DTCs 44 , to avoid any confounding effects that could result from systemic manipulations of COL IV levels, we used a strain that allows us to specifically interfere with DTC COL IV production by RNAi