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Across STEP 1, STEP 3 and STEP 4, treatment with semaglutide 2.4 mg was associated with a significant 30% HOMA-IR reduction 73

It acts on specific receptors in the brain that regulate appetite and food intake, leading to a decreased desire to eat

Less common, but milder, side effects of semaglutide injections Some side effects of semaglutide injections for weight loss seen in clinical trials are less common but still mild and include: Indigestion (dyspepsia) Dizziness Abdominal distention (bloating) Belching (eructation) Low blood sugar (hypoglycemia) in people with type 2 diabetes Flatulence Gastroenteritis Gastroesophageal reflux disease (GERD) Gastritis Gastroenteritis viral Hair loss An abnormal touch sensation (dysesthesia) These side effects were reported fewer than 9% of trial participants

N Engl J Med 2008;359:1577e89

A tiny amount is normal

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