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doi: 10.3390/nu17172790, 50

IM is typically reserved for studies where the research objective is to observe the direct effect on a specific, isolated muscle or deep tissue area

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e.g., LEADER, SUSTAIN-6, EXSCEL, HARMONY Outcomes, REWIND, ELIXA, AMPLITUDE-O, SELECT) and other large-scale clinical programs (e.g., PIONEER, AWARD, LEAD, SCALE, STEP)