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Russell et al., 2019

If you have a history of disordered eating, depression, or suicidal thoughts, you may need to hold off entirely or be extra careful by making sure you receive psychological support throughout the process

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EstroGel Side Effects to Know Below are the reported possible side effects of EstroGelthe first two were the most common in clinical trials, and the others are listed in the FDA-approved patient info: headache breast tenderness or pain irregular vaginal bleeding or spotting stomach/abdominal cramps, bloating nausea and vomiting hair loss fluid retention vaginal yeast infection skin irritation at the application site Risks, Precautions, and Who May Not Be a Good Candidate EstroGel is generally well tolerated , but people with certain health histories or symptoms may not be a good candidate for it