Decomposition of lipid peroxides can lead to protein-reactive metabolites, e.g., 4-hydroxynonenal, whereas the oxidation of DNA bases can lead to reactive adenine propenal (Figure 4c,d) [38,47]
We often see a decline in glutathione levels with aging , as well as with many forms of neurological , respiratory and metabolic dysfunction (22-23)
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Further, 117 or 12 scans were accumulated for the samples with microsomes or whole cells, respectively
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The diminished contractility was associated with the reduction in Ca 2+ release suggesting that changes in Ca 2+ cycling underly reduced cardiac contractility