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IUBMB Life 72:18791890

Neuropharmacology 150:112120 McQueen G, Lally J, Collier T, Zelaya F, Lythgoe DJ, Barker GJ et al (2018) Effects of N-acetylcysteine on brain glutamate levels and resting perfusion in schizophrenia

strong depolarization of the post-synaptic cell completely displaces the magnesium ions that block NMDA ion channels and allows calcium ions to enter a cell probably causing LTP, while weaker depolarization only partially displaces the Mg 2+ ions, resulting in less Ca 2+ entering the post-synaptic neuron and lower intracellular Ca 2+ concentrations (which activate protein phosphatases and induce long-term depression, LTD)

NAD+ helps with energy production and sirtuin activation, while glutathione neutralizes harmful free radicals and aids detoxification

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