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Evidence suggests that hepatic GHS-R1a is functionally coupled to Gq-PLC-IP-Ca-PKC and Gi-cAMP signalling in hepatocytes, mirroring the dual-coupling pharmacology observed in other tissue types

doi: 10.1016/j.chembiol.2023.10.011 174 ChenHZhongYSangWWangCLuHLaiPet al

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The molecular responses observed vary according to receptor subtype, peptide concentration, exposure time, cell model, and overall study design, and MTII is employed to characterise melanocortinreceptor signalling rather than to infer defined biological or physiological effects