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Supportive of this notion, a proof-of-concept study performed by Coopmans et al

The oral daily dose far exceeds the vitamin requirement because the normal transporter protein-mediated absorption is absent, leaving only very inefficient intestinal passive absorption

However, Tregs can also adopt an inflammatory effector-like phenotype and lose their suppressive capacity due to chronic inflammation, metabolic reprogramming, tissue-specific reprogramming, and possibly insufficient IL-2 signaling 113,114