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InnoSlim, a combination of Astragalus membranaceus and Panax notoginseng, has also been shown to activate AMPK as well as increase the level of the key hormone adiponectin

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Kahlson MA, Dixon SJ

The 2025 Frontiers in Aging clinical review (Frontiers in Aging 2025) summarises the documented short-term adverse effects in adult populations: peripheral oedema and fluid retention are common at initiation, carpal tunnel syndrome occurs in a meaningful proportion of users, hyperglycaemia and insulin resistance can emerge because GH is physiologically counter-regulatory to insulin, and gynaecomastia has been reported, particularly at higher doses

Gao et al., 2012, 2017