downsides of semaglutide Comparative safety and side effects and tirzepatide: Implications for clinical decision-making in obesity management Semaglutide Side Effects: What to

A recent study published in Diabetes Obesity and Metabolism found that individuals using these medications lost significant amounts of fat but also experienced some degree of muscle loss, with lean body mass reductions making up approximately 25%40% of total weight Trusted Source Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies Neeland IJ, Linge J, Birkenfeld AL Go to Source loss

Metabolic rate generally tracks with body weight

Contact your healthcare provider if you experience persistent or severe abdominal discomfort

Many patients begin noticing reduced appetite within the first few weeks, with visible weight loss typically developing over several months as dosing is gradually increased

Current Opinion in Clinical Nutrition and Metabolic Care, 7 (4), 405410

In other words, youll want to make sure the new compounded semaglutide product comes from a reliable provider