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For instance, in April 2023, Eli Lilly and Company notified that tirzepatide 10 mg and 15 mg demonstrated 15.7% weight loss in adults with obesity and type 2 diabetes in 72 weeks, resulting from SURMOUNT-2 clinical trials

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Mechanistic insights also reveal that GLP-1RAs modulate inflammasome activity, specifically the NLRP3 inflammasome, thus reducing pyroptosis and inflammatory cell death in hepatic and immune cells (29)