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doi: 10.1016/j.jafr.2025.102429 132

The repetitive stress of striking, the torque applied to joints during grappling, and the accumulated microtrauma from years of training create a constellation of injury risks that few other athletic pursuits can match

This decline can manifest in decreased energy levels, slower healing, reduced muscle mass, and weakened immune responses

For time-dependent measurements (mechanical and cold allodynia tests), statistical comparisons were performed using two-way ANOVA followed by Tukeys post-hoc test

Thiol of reactive cysteine on proteins (P-SH) is another important target of reactive oxygen/nitrogen species (ROS/RNS) signaling pathway because it can be oxidized at a different extent up to the sulfonic form (P-SO 3 H), an irreversible oxidation product