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For example, Bifidobacterium bifidum [138], with its hypoxia tropism, has been used to covalently modify calcium phosphate/silica nanoparticles loaded with doxorubicin, constructing the DNPs@Bi system that can actively target chemotherapy drugs to the hypoxic core of tumors, achieving effective killing of solid tumors through the combination of chemotherapy and immunogenic cell death effects

28,29 SYNCHRONIZE-JP explores the relative change in liver fat and body composition parameters from baseline to Week 76 when treated with survodutide versus placebo, as a secondary endpoint

Firstly, NAFLD and HFpEF share common risk factors

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