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2020;40:BSR20193314

In one study, chronic treatment with a low dose of clozapine (0.5 mg/kg) increased the number of bromodeoxyuridine (BrdU)-positive cells in the dentate gyrus 24 hours after BrdU administration, whereas haloperidol (0.05 or 2 mg/kg) or a high dose of clozapine (20 mg/kg) had no significant effect.134 Interestingly, the increased BrdU-positive cells with a low dose of clozapine could not survive or integrate into existing hippocampal circuitry

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He is a graduate of LaSau College and the College of osteopathic medicine and surgery

This guidance recommends stopping medication in patients who have not lost more than 5% of weight after six months of treatment

Therapeutic modulation of this axis represents a promising approach to mitigating renal injury