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Long-chain acylcarnitines were significantly lower in congenital hypothyroid patients (2.67 0.87 mol/L) compared to controls (3.15 0.93 mol/L

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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

Bacteriostatic water's 0.9% benzyl alcohol preservative prevents bacterial growth in reconstituted solutions, extending stable storage from 72 hours to 28-30 days when refrigerated

J Trace Elem Med Biol 19:203208