EARLY WORK DEFINING THE INSULIN-GH-IGF-AXIS Daughaday realized that the mitogenic effect of GH in the growth plate was not direct but mediated by Insulin-like Growth Factor-I (IGF-I), at that time named sulphation factor or somatomedin C (1)
Nanba, K
These substances activate the bodys stress response system, flooding the bloodstream with cortisol and other stress hormones that directly interfere with hair follicle function
The documented mechanisms are: VEGF stimulation in dermal fibroblasts that supports the microvascular network feeding the follicle, collagen and glycosaminoglycan synthesis at the follicular basement membrane, anti-inflammatory signaling that calms the chronic micro-inflammation associated with androgenetic alopecia, and direct follicular signaling that extends the anagen growth phase
If you experience sudden, severe weakness in your leg, loss of bladder or bowel control, or numbness in your groin area, get to an emergency room immediately
10.1159/000516396 144 LiuQ.WangJ.GuZ.OuyangT.GaoH.KanH.et al (2024)
