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Therefore, -blockers are hypothesized to alter the tumor microenvironment, thereby providing a protective role in cancer (Wrobel et al., 2020

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Other details are described in Supplementary Methods

In particular, FLNA mutations cause periventricular nodular heterotopia, a brain malformation due to abnormal neuronal migration, in which a subset of neurons fails to migrate into the developing cerebral cortex (73) or a wide spectrum of congenital malformations, such as otopalotodigital syndrome, frontometaphyseal dysplasia, and Melnick Needles syndrome (74)