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However, the conservative approach is waiting until skeletal maturity and the early 20s when growth plates are fully closed and endocrine systems are mature
But the results tend to be more durable because the underlying metabolic drivers have changed, not just suppressed
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One small nondiabetic study showed a 6.5% weight loss with sitagliptin versus 7.65% with metformin, but larger studies in T2DM have not confirmed a direct effect on weight
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