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How retatrutide and Wegovy work Both medications work on the bodys appetite-regulating hormones, but they target different ones, which is why the trial results differ

However, further studies are needed to conclusively clarify the mechanisms underlying these protective effects

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GLP-1 RA users also had a lower prevalence of chronic kidney disease, atrial fibrillation, and ischemic heart disease, but a higher prevalence of insulin use at baseline