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GnRH agonists like leuprolide create a temporary menopause state, reducing pain in 85-90% of patients within 3 months, but bone loss limits use to 6-12 months without add-back therapy

Preclinical evidence links MOTS-c to reduced myostatin signaling - myostatin is the protein that limits muscle growth, so less of it makes it easier to keep muscle during a deficit

This represents an epigenetic regulatory pathway distinct from the peptides telomerase and melatonin activities

Today's PCAC hearing is the formal process for deciding whether to open a legal compounding pathway but even a favorable vote would not produce legally compounded BPC-157 for at least 12 to 24 months while rulemaking proceeds