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Finally, this unique phenotype offers mechanistic insights: the dissociation between severe adiposity and a favorable cardiometabolic profile suggests that MC4R signaling plays a non-redundant role in integrating energy balance with cardiovascular regulation [2,32,33]

57, 48, and 158%, respectively) higher in TMX-treated rats, while HDL-C was significantly lower (Fig

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The safety profile of tirzepatide was similar to that of GLP-1 receptor agonists, with gastrointestinal events being the most common adverse events

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