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At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

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They placed 100 obese children and teens between the ages of six and 18 years on a reduced calorie diet and then randomly assigned them to receive either a Bifidobacteria probiotic or a placebo

Realdon, S

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