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DNA Deoxyribonucleic acid bases and phosphodiester backbones are susceptible to oxidative stress (inflammation), and peroxidation of these structures can cause strand breaks and cross-linking of the DNA and result in disrupted transcription, translation, and DNA replication It has been suggested that damaged genomic DNA of the spermatozoa can be transmitted to the offspring and lead to increased incidences of miscarriage, fetal anomalies, and birth defects They went on to show that treatment with Vitamin C and Glutathione reduced the level of hydroxy-2-deoxyguanosine which is a measure of DNA oxidative damage

TLR4 activation may lead to ROS signaling via direct interaction between TLR4 and NADPH oxidase (Gill et al., 2010

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The mutations in the G6PD gene are deleterious and, thus, theoretically should have been weeded out of the genome, according to the normal way that mutations work in a population