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Beyond gastrointestinal effects, clinical data and class-level evidence from licensed incretin agents (semaglutide, tirzepatide) have flagged concerns regarding: Heart rate elevation: Increases in resting heart rate are a recognised class effect of GLP-1 receptor agonists, documented in the SmPCs for semaglutide (Wegovy) and tirzepatide (Mounjaro)

This finding suggests a promising strategy for improving hyperthermic purging in leukemia treatment [1]

In some rare cases, such as when a tophus is infected or when its location is causing major disability, surgical removal may be considered

3 November 2022

Keywords: vitamin B, serotonin, dopamine, homocysteine, bariatric surgery, pro-inflammatory cytokines 1

Mild signs of hypersensitivity: itching or rash