Glass, Cagri Senyucel and Julia P
Along with generally increased difficulty associated with physical functioning, obesity comes with a long list of side effects, most of which are fairly serious and lead to an increased risk of death
The results were heterogeneous: some trials, such as AMPLITUDE-O and SELECT, demonstrated significant reductions in HF-related endpoints, whereas others, like LEADER, showed only non-significant favourable trends
Due to the strong acidic environment of the stomach and the characteristics of the digestive peristalsis of the stomach, it had always been considered that the stomach was a sterile organ without microbiota
In the clinical experience of some authors of this Advisory, another approach is to maintain individuals at the lowest effective dose and escalate only as needed (i.e., when weight reduction ceases or efficacy wanes), although shortages of medications at lower doses may be a barrier
We've seen patients get so discouraged by this process that they give up entirely before even starting treatment
