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Clinical resistance arises because anticancer therapies rarely eliminate all malignant cell states simultaneously ( 1.2 Historical perspective and the evolution of the heterogeneity paradigm The recognition of tumors as heterogeneous systems predates modern genomics

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Supports metabolism and helps maintain healthy blood lipids

Both UroA and spermidine increase the activity of SIRT1, and thus the expression and function of LC3, while inhibiting mTOR activity