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These medications require careful dose escalation, side effect monitoring, and follow-up to ensure safety and effectiveness, especially for people with thyroid or metabolic conditions.

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211 ERAD and the UPR are intimately linked, enabling ERAD to ensure protein quality and quantity, to induce gene expression programs, and to maintain normal physiology

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In post-menopause, she experienced arthritic degeneration (in the hands bilaterally) treated with cortisone therapy for short periods, and osteoporosis that was not controlled despite medication: vertebral and then costal fractures

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